isrupted in Schizophrenia 1 Genotype and Positive ymptoms in Schizophrenia
نویسندگان
چکیده
ackground: Converging evidence has demonstrated an association between the Disrupted in Schizophrenia 1 (DISC1) gene and schizohrenia (SZ). Within the DISC1 gene, a single nucleotide polymorphism (SNP), Ser704Cys, has been associated with the structure and unction of the hippocampus. Because positive symptoms in SZ have also been associated with hippocampal structure and function, we ypothesized that variation in a DISC1 haplotype containing Ser704Cys would be significantly associated with positive symptomatology in SZ.
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